2024
Functional and morphological adaptation of medial prefrontal corticotropin releasing factor receptor 1-expressing neurons in male mice following chronic ethanol exposure
Reesha R. Patel*, Pauravi Gandhi*, Kathryn Spencer, Nihal A. Salem, Chloe. M. Erikson, Vittoria Borgonetti, Roman Vlkolinsky, Larry Rodriguez, Tali Nadav, Michal Bajo, Amanda J. Roberts, R. Dayne Mayfield, Marisa Roberto
*Equal Contribution
Neurobiology of Stress, https://doi.org/10.1016/j.ynstr.2024.100657 Read PDF
2023
Social isolation recruits amygdala-cortical circuitry to escalate alcohol drinking
Reesha R. Patel, Makenzie Patarino, Kelly Kim, Rachelle Pamintuan, Felix Taschbach, Hao Li, Christopher Lee, Aniek van Hoek, Rogelio Castro, Christian Cazares, Ray Miranda, Caroline Jia, Jeremy Delahanty, Kanha Batra, Laurel Keyes, Avraham Libster, Romy W. Wichmann, Talmo Pereira, Marcus Benna, & Kay M. Tye
BioRxiv, doi: https://doi.org/10.1101/2023.11.09.566421 Read PDF
2022
Amygdalostriatal transition zone neurons encode sustained valence to direct conditioned behaviors
Fergil Mills*, Christopher R. Lee*, James R. Howe *, Hao Li*, Shan Hao, Maria N. Keisler, Mackenzie E. Lemieux, Felix H. Taschbach, Laurel R. Keyes, Matilde Borio, Hannah S. Chen, Reesha R. Patel, Alexa L. Gross, Jeremy Delahanty, Christian Cazares, Liezl Maree, Romy Wichmann, Talmo D. Pereira, Marcus K. Benna, Cory M. Root, & Kay M. Tye.
BioRxiv, doi: 10.1101/2022.10.28.514263
Blockade of orexin receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol-seeking behaviour in alcohol-dependent rats.
Francisco J. Flores-Ramirez, Florence P. Varodayan, Reesha R. Patel, Jessical M. Illenberger, Francesca Di Ottavio, Marisa Roberto, & Rémi Martin-Fardon
British Journal of Pharmacology, doi: 10.1111/bph.16015 Read PDF
Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein
Carolina L. Haass-Koffler, Chase Francis, Pauravi Gandhi, Reesha R. Patel, Mohammad Naemuddin, Carsten K. Nielsen, Selena E. Barlett, Antonello Bonci, Stefan Vasile, Becky L. Hood, Eigo Suyama, Michael P. Hendrick, Layton H. Smith, Allison S. Limpert, Marisa Roberto, Nicholas D. P. Cosford, & Douglas J. Sheffler
SLAS Discovery, doi 10.1016/j.slasd.2022.09.005 Read PDF
Ethanol withdrawal-induced adaptations in prefrontal corticotropin releasing factor receptor 1-expressing neurons regulate anxiety and conditioned rewarding effects of ethanol
Reesha R. Patel, Sarah A. Wolfe, Vittoria Borgonetti, Pauravi J. Gandhi, Larry Rodriguez, Angela E. Snyder, Shannon D’Ambrosio, Michal Bajo, Alain Domissy, Steven Head, Candice Contet, R. Dayne Mayfield, Amanda J. Roberts, & Marisa Roberto
Molecular Psychiatry, doi: 10.1038/s41380-022-01642-3 Read PDF
Alcohol dependence induces CRF sensitivity in female central amygdala GABA syanpses
Larry Rodriguez, Dean Kirson, Sarah A. Wolfe, Reesha R. Patel, Florence P. Varodayan, Angela E. Snyder, Pauravi J. Gandhi, Sophia Khom, Roman Vlkolinsky, Michal Bajo, & Marisa Roberto
International Journal of Molecular Sciences, doi: 10.3390/ijms23147842 Read PDF
The amygdala noradrenergic system is compromised with alcohol use disorder
Florence P. Varodayan, Reesha R. Patel, Alessandra Matzeu, Sarah A. Wolfe, Dallece E. Curley, Sophia Khom, Pauravi J. Gandhi, Larry Rodriguez, Michal Bajo, Shannon D’Ambrosio, Hui Sun, Tony M. Kerr, Rueben A. Gonzales, Lorenzo Leggio, Luis A. Natividad, Carolina L. Haass-Koffler, Remi Martin-Fardon, & Marisa Roberto
Biological Psychiatry, doi: 10.1016/j.biopsych.2022.02.006 Read PDF
Cortical ensembles orchestrate social competition through hypothalamic outputs
Nancy Padilla-Coreano, Kanha Batra, Makenzie Patarino, Zexin Chen, Rachel R. Rock, Ruihan Zhang, Sébastien B Hausmann, Javier C Weddington, Reesha R. Patel, Yu E. Zhang, Hao-Shu Fang, Srishti Mishra, Deryn O. LeDuke, Jasmin Revanna, Hao Li, Matilde Borio, Rachelle Pamintuan, Aneesh Bal, Laurel R. Keyes, Avraham Libster, Romy Wichmann, Fergil Mills, Felix H Taschbach, Gillian A. Matthews, James P. Curley, Ila R. Fiete, Cewu Lu, & Kay M. Tye
2021
Synaptic effects of IL-1β and CRF in the central amygdala after protracted alcohol abstinence in male rhesus macaques
Reesha R. Patel*, Florence P. Varodayan* , Melissa A. Herman, Vanessa Jimenez, Rebecca Agnore, Lina Gao, Michal Bajo, Verginia C. Cuzon Carlson, Nicole A. Walter, Suzanne S. Fei, Kathleen A. Grant, & Marisa Roberto
*Equal Contribution
Neuropsychopharmacology, doi: 10.1038/s41386-021-01231-y Read PDF
IL-10 normalizes aberrant amygdala GABA transmission and reverses anxiety-like behavior and dependence-induced escalation of alcohol intake
Reesha R. Patel, Sarah A. Wolfe, Michal Bajo, Shawn Abeynaike, Amanda Pahng, Vittoria Borgonetti, Shannon D'Ambrosio, Rana Nikzad, Scott Edwards, Silke Paust, Amanda J. Roberts, & Marisa Roberto
Progress in Neurobiology, doi: 10.1016/j.pneurobio.2020.101952 Read PDF
Sex differences in acute alcohol sensitivity of naïve and alcohol dependent central amygdala GABA synapses
Dean Kirson, Sophia Khom, Larry Rodriguez, Sarah A. Wolfe, Florence P. Varodayan, Pauravi J. Gandhi, Reesha R. Patel, Roman Vlkolinsky, Michal Bajo, & Marisa Roberto
Alcohol and Alcoholism, doi: 10.1093/alcalc/agab034 Read PDF
Valence processing in the PFC: Reconciling circuit-level and systems-level views
Austin A. Coley, Nancy Padilla-Coreano*, Reesha R. Patel*, & Kay M. Tye
*Equal Contribution
International Review of Neurobiology, doi: 10.1016/bs.irn.2020.12.002 Read PDF
2020
Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice
Kayla Frank, Shawn Abeynaike ,Rana Nikzad, Reesha R. Patel, Amanda J. Roberts, Marisa Roberto, & Silke Paust
PLoS One, doI; 10.1371/journal.pone.0239246 Read PDF
Alcohol dependence and withdrawal impair serotonergic regulation of GABA transmission in the rat central nucleus of the amygdala
Sophia Khom, Sarah A. Wolfe, Reesha R. Patel, Dean Kirson, David M. Hedges, Florence P. Varodayan, Michal Bajo, & Marisa Roberto
Journal of Neuroscience, doi: 10.1523/JNEUROSCI.0733-20.2020 Read PDF
Microglia Control Escalation of Drinking in Alcohol-Dependent Mice: Genomic and Synaptic Drivers
Anna S. Warden, Sarah A. Wolfe, Sophia Khom, Florence P. Varodayan, Reesha R. Patel, Michael Q. Steinman, Michal Bajo, Sarah E. Montgomery, Roman Vlkolinsky, Tali Nadav, Ilham Polis, Amanda J. Roberts, R. Dayne Mayfield, R. Adron Harris, & Marisa Roberto
Biological Psychiatry, doi: 10.1016/j.biopsych.2020.05.011 Read PDF
Preferential Pharmacological Inhibition of Nav1.6, but not Nav1.1, Abolishes Epileptiform Activity Induced by 4-AP in Mouse Cortical Slices
Reesha R. Patel, Xingjie Ping, Shaun R. Patel, Jeff S. McDermott, Jeffrey L. Krajewski, Xian Xuan Chi, Eric S. Nisenbaum, Xiaoming Jin, & Theodore R. Cummins
bioRxiv, doi: 10.1101/2020.05.29.124693 Read PDF
2019
Role of MyD88 in IL-1β and Ethanol Modulation of GABAergic Transmission in the Central Amygdala
Michal Bajo, Reesha R. Patel, David M. Hedges, Florence P. Varodayan, Roman Vlkolinsky, Tony D. Davis, Michael D. Burkart, Yuri A. Blednov, & Marisa Roberto
Brain Sciences, doi: 10.3390/brainsci9120361 Read PDF
Resurgent and Gating Pore Currents Induced by De Novo SCN2A Epilepsy Mutations
Emily R. Mason, Fenfen Wu, Reesha R. Patel, Yucheng Xiao, Stephen C. Cannon, & Theodore R. Cummins
Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala
Juan Suárez, Sophia Khom, Francisco Alén, Luis A Natividad, Florence P. Varodayan, Reesha R. Patel, Dean Kirson, Rocío Arco, Antonio Ballesta, Michal Bajo, Leticia Rubio, Rémi Martin-Fardon, Fernando Rodríguez de Fonseca, & Marisa Roberto
Addiction Biology, doi: 10.1111/adb.12813 Read PDF
Molecular, Morphological, and Functional Characterization of Corticotropin-Releasing Factor Receptor 1-Expressing Neurons in the Central Nucleus of the Amygdala
Sarah A. Wolfe*, Harpreet Sidhu*, Reesha R. Patel*, Max Kreifeldt, Shannon R. D’Ambrosio, Candice Contet*, and Marisa Roberto*
*Equal contribution
2018
IL-1β expression is increased and regulates GABA transmission following chronic ethanol in mouse central amygdala
Reesha R. Patel, Sophia Khom, Michael Q. Steinman, Florence P. Varodayan, William B. Kiosses, David M. Hedges, Roman Vlkolinsky, Tali Nadav, Ilham Polis, Michal Bajo, Amanda J. Roberts, & Marisa Roberto
Brain, Behavior, and Immunity, doi: 10.1016/j.bbi.2018.10.009 Read PDF
Structural Analysis of Hippocampal Kinase Signal Transduction
Daniel B. McClatchy, Nam-Kyung Yu, Salvador Martínez-Bartolomé, Reesha R. Patel, Alexander R. Pelletier, Mathieu Lavalle-Adam, Susan B. Powell, Marissa Roberto, & John R. Yates
ACS Chemical Neuroscience, doi: 10.1021/acschemneuro.8b00284 Read PDF
Withdrawal-induced escalated oxycodone self-administration is mediated by kappa opioid receptor function
Jacques D. Nguyen, Dean Kirson, Michael Q. Steinman, Reesha R. Patel, Sophia Khom, Florence P. Varodayan, David M. Hedges, Christopher S. Oleata, Yanabel Grant, Marisa Roberto, & Michael A. Taffe
bioRxiv, doi: 10.1101/177899 Read PDF
Role of TLR4 in the Modulation of Central Amygdala GABA Transmission by CRF Following Restraint Stress
Florence P. Varodayan, Sophia Khom, Reesha R. Patel, Michael Q. Steinman, David M. Hedges, Christopher S. Oleata, Gregg E. Homanics, Marisa Roberto, & Michal Bajo
Alcohol and Alcoholism, doi: 10.1093/alcalc/agx114 Read PDF
2017
Ethanol and Cytokines in the Central Nervous System
Marisa Robert, Reesha R. Patel, & Michal Bajo
Handbook of Experimental Pharmacology, doi: 10.1007/164_2017_77 Read PDF
2016
Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol
Reesha R. Patel, Cindy Barbosa, Tatiana Brustovetsky, Nickolay Brustovetsky, Theodore R. Cummins
2015
Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons
Cindy Barbosa, Zhi-Yong Tan, Ruizhong Wang, Wenrui Xie, Judith A. Strong, Reesha R. Patel, Michael R. Vasko, Jun-Ming Zhang, Theodore R. Cummins
Molecular Pain, doi: 10.1186/s12990-015-0063-9 Read PDF
Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction
Reesha R. Patel, Cindy Barbosa, Yucheng Xiao, Theodore R. Cummins
PLoS One, doi: 10.1371/journal.pone.0133485 Read PDF